Cameron Mura

About

I'm a Senior Scientist and co-director of the Bourne & Mura Computational Biosciences Lab, based in the Department of Biomedical Engineering and School of Data Science at the University of Virginia; earlier on, I was an Assistant Professor of Chemistry at UVA (2008-2018). My scientific background, and most of my research interests, are in the areas of structural biology, molecular biophysics and computational biology, particularly as regards the evolution of RNA-associated ribonucleoprotein assemblies, protein folds, and protein-protein interactions. I'm also interested in data science and its attendant approaches (e.g., deep learning and other machine learning paradigms), chiefly as applied to the aforementioned scientific domains. Further information is available at http://bournelab.org.

Work

University of Virginia

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Senior Scientist

US

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University of Virginia

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Assistant Professor

US

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University of Virginia

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Research Assistant Professor

US

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Education

University of California Los Angeles

United States of America
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PhD, Biochemistry & Molecular Biology

Georgia Institute of Technology

United States of America
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BS, Chemistry, with highest honors

Publications

A Tribute to Phil Bourne—Scientist and Human

Biomolecules

journal-article

Ten simple rules for serving as an editor

PLOS Computational Biology

journal-article

A Tribute to Phil Bourne—Scientist and Human

Biomolecules

journal-article

A Comparative Analysis of COVID-19 Vaccines Based on over 580,000 Cases from the Vaccination Adverse Event Reporting System

Vaccines

journal-article

Deep Generative Models of Protein Structure Uncover Distant Relationships Across a Continuous Fold Space

preprint

A Comparative Analysis of COVID-19 Vaccines Based on over 580,000 Cases from the Vaccination Adverse Event Reporting System

Vaccines

journal-article

Prop3D: A Flexible, Python-based Platform for Machine Learning with Protein Structural Properties and Biophysical Data

preprint

Ten Simple Rules for Serving as an Editor

preprint

Explainable Deep Generative Models, Ancestral Fragments, and Murky Regions of the Protein Structure Universe

preprint

IL-13 Is a Driver of COVID-19 Severity

JCI Insight

journal-article

Real-world Evidence for Improved Outcomes with Histamine Antagonists and Aspirin in 22,560 COVID-19 Patients

other

A Birds-eye (Re)View of Acid-suppression Drugs, COVID-19, and the Highly Variable Literature

preprint

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

Signal Transduction and Targeted Therapy

journal-article

Real-world Evidence for Improved Outcomes with Histamine Antagonists and Aspirin in 22,560 COVID-19 Patients

preprint

Clinical Evidence for Improved Outcomes with Histamine Antagonists and Aspirin in 22,560 COVID-19 Patients

other

Evidence for Treatment with Estradiol for Women with SARS-CoV-2 Infection

BMC Medicine

journal-article

Evidence for treatment with estradiol for women with SARS-CoV-2 infection

other

Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2.

Frontiers in Chemistry

journal-article

Ten Simple Rules for Starting Research in Your Late Teens

PLOS Computational Biology

journal-article

Deep Learning of Protein Structural Classes: Any Evidence for an ‘Urfold’?

2020 Systems and Information Engineering Design Symposium (SIEDS)

conference-paper

The Urfold : Structural similarity just above the superfold level?

Protein Science

journal-article

Ten Quick Tips for Using a Raspberry Pi

PLOS Computational Biology

journal-article

Machine Learning for Classification of Protein Helix Capping Motifs

2019 Systems and Information Engineering Design Symposium (SIEDS)

conference-paper

Stimuli-Responsive, Pentapeptide, Nanofiber Hydrogel for Tissue Engineering

Journal of the American Chemical Society

journal-article

The Small β-Barrel Domain: A Survey-Based Structural Analysis

Structure

journal-article

Structural Biology Meets Data Science: Does Anything Change?

Current Opinion in Structural Biology

journal-article

Producing Hfq/Sm Proteins and sRNAs for Structural and Biophysical Studies of Ribonucleoprotein Assembly

Methods in Molecular Biology (Clifton, N.J.)

book-chapter

Crystal Structure and RNA-binding Properties of an Hfq Homolog from the Deep-branching Aquificae: Conservation of the Lateral RNA-binding Mode

Acta Crystallographica, Section D: Structural Biology

journal-article

Understanding the Results of Electrostatics Calculations: Visualizing Molecular 'Isopotential' Surfaces

preprint

Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-Mimetic, Elastin-Like Fusion Protein

Biomacromolecules

journal-article

An Introduction to Programming for Bioscientists: A Python-Based Primer

PLoS Computational Biology

journal-article

Claws, Disorder, and Conformational Dynamics of the C-Terminal Region of Human Desmoplakin

The Journal of Physical Chemistry, B

journal-article

Known Structure, Unknown Function: An Inquiry-based Undergraduate Biochemistry Laboratory Course

Biochemistry & Molecular Biology Education

journal-article

Interplay of the Bacterial Ribosomal A-site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study

PLOS ONE

journal-article

An Introduction to Biomolecular Simulations and Docking

Molecular Simulation

journal-article

Development & Implementation of a PyMOL 'putty' Representation

preprint

Archaeal and Eukaryotic Homologs of Hfq: A Structural and Evolutionary Perspective on Sm Function

RNA Biology

journal-article

Rapid Colorimetric Assays to Qualitatively Distinguish RNA and DNA in Biomolecular Samples

Journal of Visualized Experiments (JoVE)

journal-article

A Lightweight, Flow-based Toolkit for Parallel and Distributed Bioinformatics Pipelines

BMC Bioinformatics

journal-article

Abstractions, Algorithms and Data Structures for Structural Bioinformatics in PyCogent

Journal of Applied Crystallography

journal-article

Molecular Dynamics of Potential rRNA Binders: Single-Stranded Nucleic Acids and Some Analogues

The Journal of Physical Chemistry, B

journal-article

An Introduction to Biomolecular Graphics

PLoS Computational Biology

journal-article

RapA, the SWI/SNF Subunit of Escherichia coli RNA Polymerase, Promotes the Release of Nascent RNA from Transcription Complexes

Biochemistry

journal-article

PaPy: Parallel and Distributed Data-processing Pipelines in Python

Proceedings of the 8th Python in Science Conference

conference-paper

Molecular Dynamics of a κB DNA Element: Base Flipping via Cross-strand Intercalative Stacking in a Microsecond-scale Simulation

Nucleic Acids Research

journal-article

Sm-like Protein Hfq: Location of the ATP-binding Site and the Effect of ATP on Hfq•RNA Complexes

Protein Science

journal-article

Three-dimensional Structures of Fibrillar Sm Proteins: Hfq and Other Sm-like Proteins

Journal of Molecular Biology

journal-article

The Oligomerization and Ligand-binding Properties of Sm-like Archaeal Proteins (SmAPs)

Protein Science

journal-article

Structure and Assembly of an Augmented Sm-like Archaeal Protein 14-mer

Proceedings of the National Academy of Sciences, USA (PNAS)

journal-article

Structure and Function of an Archaeal Homolog of Survival Protein E (SurEα): An Acid Phosphatase with Purine Nucleotide Specificity

Journal of Molecular Biology

journal-article

The Structures, Functions, and Evolution of Sm-like Archaeal Proteins (SmAPs)

dissertation-thesis

Structure of a Nudix Protein from Pyrobaculum aerophilum Reveals a Dimer with Two Intersubunit β–sheets

Acta Crystallographica Section D: Biological Crystallography

journal-article

The Crystal Structure of a Heptameric Archaeal Sm Protein: Implications for the Eukaryotic SnRNP Core

Proceedings of the National Academy of Sciences, USA (PNAS)

journal-article

Oxyanion-mediated Inhibition of Serine Proteases

Biochemistry

journal-article